Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease
Identifieur interne : 001417 ( Main/Exploration ); précédent : 001416; suivant : 001418Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease
Auteurs : Colum D. Mackinnon [États-Unis] ; Ruth M. Webb [Royaume-Uni] ; Paul Silberstein [Royaume-Uni] ; Steven Tisch [Royaume-Uni] ; Peter Asselman [Royaume-Uni] ; Patricia Limousin [Royaume-Uni] ; John C. Rothwell [Royaume-Uni]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2005-03.
English descriptors
- KwdEn :
Abstract
High‐frequency electrical stimulation through electrodes implanted in the subthalamic nucleus (STN) has been shown to reduce significantly the cardinal symptoms of Parkinson's disease (PD). Despite the success of this treatment, the mechanisms of action of stimulation are poorly understood. To elucidate further the mechanisms of action of deep brain stimulation and its effects on cortical activity, we recorded electroencephalographic potentials from 61 scalp‐surface electrodes during low‐frequency (5–10 Hz) bipolar stimulation in 11 patients with advanced PD (14 implanted electrodes were tested). In all electrodes tested, stimulation through at least one of the four contacts produced a medium‐latency waveform with an average onset of 14 ± 3 ms and peak at 23 ± 4 ms. This potential typically increased in magnitude across contacts from ventral to dorsal. Within‐subject comparisons of median nerve somatosensory evoked potentials demonstrated that the generator of the medium‐latency potential was within the primary sensorimotor cortex or lateral premotor cortex ipsilateral to stimulation. The timing and topography of this potential were consistent with indirect activation of the cortex by excitation of pallido‐thalamic axons that traverse the dorsal aspect of the STN. The potential evoked by stimulation through the contact used for optimal clinical effect was highly variable across electrodes and frequently different from the medium‐latency potential described above, suggesting that the neuronal elements mediating the medium‐latency potential were different from those that mediate the clinical effects.
Url:
DOI: 10.1111/j.1460-9568.2005.03952.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease</title><author><name sortKey="Mackinnon, Colum D" sort="Mackinnon, Colum D" uniqKey="Mackinnon C" first="Colum D." last="Mackinnon">Colum D. Mackinnon</name></author><author><name sortKey="Webb, Ruth M" sort="Webb, Ruth M" uniqKey="Webb R" first="Ruth M." last="Webb">Ruth M. Webb</name></author><author><name sortKey="Silberstein, Paul" sort="Silberstein, Paul" uniqKey="Silberstein P" first="Paul" last="Silberstein">Paul Silberstein</name></author><author><name sortKey="Tisch, Steven" sort="Tisch, Steven" uniqKey="Tisch S" first="Steven" last="Tisch">Steven Tisch</name></author><author><name sortKey="Asselman, Peter" sort="Asselman, Peter" uniqKey="Asselman P" first="Peter" last="Asselman">Peter Asselman</name></author><author><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F85587B62741D9B12F27C2B70474B38317701B3F</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1460-9568.2005.03952.x</idno><idno type="url">https://api.istex.fr/document/F85587B62741D9B12F27C2B70474B38317701B3F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001435</idno><idno type="wicri:Area/Main/Curation">001219</idno><idno type="wicri:Area/Main/Exploration">001417</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease</title><author><name sortKey="Mackinnon, Colum D" sort="Mackinnon, Colum D" uniqKey="Mackinnon C" first="Colum D." last="Mackinnon">Colum D. Mackinnon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 1100, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Webb, Ruth M" sort="Webb, Ruth M" uniqKey="Webb R" first="Ruth M." last="Webb">Ruth M. Webb</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Silberstein, Paul" sort="Silberstein, Paul" uniqKey="Silberstein P" first="Paul" last="Silberstein">Paul Silberstein</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tisch, Steven" sort="Tisch, Steven" uniqKey="Tisch S" first="Steven" last="Tisch">Steven Tisch</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Asselman, Peter" sort="Asselman, Peter" uniqKey="Asselman P" first="Peter" last="Asselman">Peter Asselman</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Science Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-03">2005-03</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1394">1394</biblScope><biblScope unit="page" to="1402">1402</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">F85587B62741D9B12F27C2B70474B38317701B3F</idno><idno type="DOI">10.1111/j.1460-9568.2005.03952.x</idno><idno type="ArticleID">EJN3952</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cortical activation</term><term>deep brain stimulation</term><term>evoked potentials</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High‐frequency electrical stimulation through electrodes implanted in the subthalamic nucleus (STN) has been shown to reduce significantly the cardinal symptoms of Parkinson's disease (PD). Despite the success of this treatment, the mechanisms of action of stimulation are poorly understood. To elucidate further the mechanisms of action of deep brain stimulation and its effects on cortical activity, we recorded electroencephalographic potentials from 61 scalp‐surface electrodes during low‐frequency (5–10 Hz) bipolar stimulation in 11 patients with advanced PD (14 implanted electrodes were tested). In all electrodes tested, stimulation through at least one of the four contacts produced a medium‐latency waveform with an average onset of 14 ± 3 ms and peak at 23 ± 4 ms. This potential typically increased in magnitude across contacts from ventral to dorsal. Within‐subject comparisons of median nerve somatosensory evoked potentials demonstrated that the generator of the medium‐latency potential was within the primary sensorimotor cortex or lateral premotor cortex ipsilateral to stimulation. The timing and topography of this potential were consistent with indirect activation of the cortex by excitation of pallido‐thalamic axons that traverse the dorsal aspect of the STN. The potential evoked by stimulation through the contact used for optimal clinical effect was highly variable across electrodes and frequently different from the medium‐latency potential described above, suggesting that the neuronal elements mediating the medium‐latency potential were different from those that mediate the clinical effects.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Illinois</li></region><settlement><li>Londres</li></settlement></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Mackinnon, Colum D" sort="Mackinnon, Colum D" uniqKey="Mackinnon C" first="Colum D." last="Mackinnon">Colum D. Mackinnon</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Webb, Ruth M" sort="Webb, Ruth M" uniqKey="Webb R" first="Ruth M." last="Webb">Ruth M. Webb</name></region><name sortKey="Asselman, Peter" sort="Asselman, Peter" uniqKey="Asselman P" first="Peter" last="Asselman">Peter Asselman</name><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><name sortKey="Silberstein, Paul" sort="Silberstein, Paul" uniqKey="Silberstein P" first="Paul" last="Silberstein">Paul Silberstein</name><name sortKey="Tisch, Steven" sort="Tisch, Steven" uniqKey="Tisch S" first="Steven" last="Tisch">Steven Tisch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001417 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001417 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:F85587B62741D9B12F27C2B70474B38317701B3F
|texte= Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |